Livedoid vasculitis - Vasculitis Livedoide
La Vasculitis Livedoide (Livedoid vasculitis) es una enfermedad cutánea crónica que se observa predominantemente en mujeres jóvenes y de mediana edad. Un acrónimo utilizado para describir sus características es "Úlceras purpúricas dolorosas con patrón reticular de las extremidades inferiores" (PÚRPURA). Se asocia con una serie de enfermedades, incluida la hipertensión venosa crónica y las varicosidades.
☆ En los resultados de 2022 del Stiftung Warentest de Alemania, la satisfacción del consumidor con ModelDerm fue sólo ligeramente inferior que con las consultas de telemedicina pagadas.
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References
Livedoid vasculopathy es una afección cutánea poco común caracterizada por úlceras dolorosas que reaparecen en la parte inferior de las piernas.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy es una afección cutánea poco común que causa úlceras recurrentes en la parte inferior de las piernas, dejando cicatrices pálidas conocidas como atrofia blanca. Si bien la causa exacta aún no está clara, se cree que el aumento de la coagulación sanguínea (hypercoagulability) es el factor principal, mientras que la inflamación desempeña un papel secundario. Los factores que contribuyen a la coagulación incluyen los siguientes: deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. En las biopsias, la afección muestra coágulos de sangre dentro de los vasos, engrosamiento de las paredes de los vasos y cicatrices. El tratamiento implica un enfoque múltiple que se centra en prevenir los coágulos sanguíneos con medicamentos como antiplaquetarios, anticoagulantes y terapia fibrinolítica. Se pueden usar varios medicamentos para esta afección de la piel: colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy es una afección poco común en la que se producen lesiones en ambas piernas. Se cree que la formación de coágulos de sangre en vasos sanguíneos pequeños es causada por un aumento de la coagulación y una reducción de la descomposición de los coágulos, junto con daños en el revestimiento de los vasos. Es más común en mujeres, especialmente entre 15 y 50 años. Dejar de fumar, cuidar las heridas y usar medicamentos como anticoagulantes y antiplaquetarios han sido eficaces.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
