Livedoid vasculitis - Vasculitis Livedoide
La Vasculitis Livedoide (Livedoid vasculitis) es una enfermedad cutánea crónica que se presenta predominantemente en mujeres jóvenes y de mediana edad. Un acrónimo utilizado para describir sus características es «Úlceras purpúricas dolorosas con patrón reticular de las extremidades inferiores» (PÚRPURA). Se asocia con diversas patologías, incluida la hipertensión venosa crónica y las varices.
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En los resultados de 2022 del Stiftung Warentest de Alemania, la satisfacción del consumidor con ModelDerm fue sólo ligeramente inferior que con las consultas de telemedicina pagadas.
En los resultados de 2022 del Stiftung Warentest de Alemania, la satisfacción del consumidor con ModelDerm fue sólo ligeramente inferior que con las consultas de telemedicina pagadas.
Puede presentarse acompañado de dolor.
relevance score : -100.0%
ReferencesLa livedoid vasculopathy es una afección cutánea poco frecuente, caracterizada por úlceras dolorosas que reaparecen en la parte inferior de las piernas.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
La livedoid vasculopathy es una afección cutánea poco frecuente que produce úlceras recurrentes en la parte inferior de las piernas, dejando cicatrices pálidas denominadas atrofia blanca. Aunque la causa exacta aún no está clara, se considera que la hypercoagulability (hipercoagulabilidad) es el factor principal, mientras que la inflamación juega un papel secundario. Los factores que favorecen la coagulación incluyen: deficiencies in proteins C and S (deficiencias de las proteínas C y S), genetic mutations like factor V Leiden (mutaciones genéticas como el factor V Leiden), antithrombin III deficiency (deficiencia de antitrombina III), prothrombin gene mutations (mutaciones del gen de la protrombina) y high levels of homocysteine (niveles elevados de homocisteína). En las biopsias, la enfermedad muestra coágulos de sangre dentro de los vasos, engrosamiento de sus paredes y cicatrices. El tratamiento requiere un enfoque múltiple centrado en prevenir la formación de coágulos mediante medicamentos antiplaquetarios, anticoagulantes y terapia fibrinolítica. Se pueden emplear varios fármacos para esta afección cutánea: colchicine y hydroxychloroquine, vasodilatadores e inmunosupresores.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy es una afección poco frecuente que produce lesiones en ambas piernas. Se cree que la formación de coágulos de sangre en vasos pequeños se debe a un aumento de la coagulación y a una reducción de la fibrinólisis, junto con daño en el revestimiento vascular. Es más común en mujeres, especialmente entre los 15 y 50 años. Dejar de fumar, cuidar adecuadamente las heridas y utilizar medicamentos como anticoagulantes y antiplaquetarios han demostrado ser eficaces.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
